Iron Chelators as Cancer Chemotherapeutic Agents

2005-12-27 11:44:30 PM
1: Cancer Invest. 2005;23(8):683-691. Links
Cell Permeable Iron Chelators as Potential Cancer Chemotherapeutic
Agents.
Pahl PM, Horwitz LD.
University of Colorado Health Sciences Center, Department of Medicine,
Denver, Colorado, USA.
Iron is an essential micronutrient for the growth and function of all
cells. It is, therefore, an attractive target for chemotherapeutic
compounds. Numerous studies in vitro and in vivo provide evidence that
iron chelators may be effective antitumor agents. Lipophilic iron
chelators that are readily cell permeable and can bind intracellular
iron stores may selectively kill cancer cells without damaging normal
cells. In this review we discuss the role of iron in cellular processes
and how these processes differ between normal and neoplastic cells. We
also review the effects on normal and cancer cell growth of several
lipophilic iron chelators.
PMID: 16377587 [PubMed - as supplied by publisher]
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