Prostate cancer and inositol hexaphosphate

2005-11-26 08:17:35 PM
1: Anticancer Res. 2005 Jul-Aug;25(4):2891-903. Related Articles, Links
Prostate cancer and inositol hexaphosphate: efficacy and mechanisms.
Singh RP, Agarwal R.
Department of Pharmaceutical Sciences, School of Pharmacy, University
of Colorado Health Sciences Center, Denver, CO 80262, USA.
There are now extensive scientific data suggesting the potential role
of dietary and non-dietary phytochemicals in the prevention and control
of prostate cancer (PCA) growth and progression. PCA is a disease of
elderly male populations with a relatively slower rate of growth and
progression as compared to most other cancers and, therefore, is a
candidate disease for preventive intervention. Overall, PCA growth and
progression involve aberrant mitogenic and survival signaling and
deregulated cell cycle progression, accompanied by gradual accumulation
of genetic and epigenetic changes over a period of years. Several
mechanisms, including overexpression of growth, survival and angiogenic
factors and their receptors, together with a loss/decrease of tumor
suppressor p53, retinoblastoma and cyclin-dependent kinase inhibitor,
have been implicated in PCA growth and progression. Therefore,
phytochemicals targeting these molecular events could have a promising
role in PCA prevention and/or therapy. Inositol hexaphosphate (IP6) is
a major constituent of most cereals, legumes, nuts, oil seeds and
soybean. Taken orally as an over-the-counter dietary/nutrient
supplement, and is recognised as offering several health benefits
without any known toxicity. In vitro anticancer efficacy of IP6 has
been observed in many human, mouse and rat prostate cancer cells.
Completed studies also show that oral feeding of IP6 inhibits human PCA
xenograft growth in nude mice without toxicity. In a recently completed
pilot study, we observed similar preventive effects of IP6 on prostate
tumorigenesis in the TRAMP model. Mechanistic studies indicate that IP6
targets mitogenic and survival signaling, as well as cell cycle
progression, in PCA cells. IP6 is also shown to target molecular events
associated with angiogenesis. Moreover, IP6 has pleiotropic molecular
targets for its overall efficacy against PCA and, therefore, could be a
suitable candidate agent for preventive intervention of this malignancy
in humans.
Publication Types:
Review
PMID: 16080543 [PubMed - indexed for MEDLINE]
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